European journal of medicinal chemistry

Synthesis and structure-activity relationships of new ACAT inhibitors

JY Nioche, J Decerprit, D Festal

Index: Nioche, J. Y.; Decerprit, J.; Festal, D. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 5 p. 377 - 386

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Citation Number: 8

Abstract

A series of heterocyclic ureas were synthesized and their ability to inhibit arterial and intestinal ACAT was assessed in animals. The structural modifications carried out in this series led to N2-(2, 4-difluorophenyl)-N1-8-(4-fluorophenyl)-2, 3, 4, 5-tetrahydro-1- benzoxepin-5-yl-N1-n-heptylurea 21, which proved to be very active on both the inhibition of aortic ACAT and the inhibition of rat cholesterol intestinal absorption, thus exhibiting a ...