An efficient method for synthesis of symmetrical diketones via reaction of. alpha.-amino-. alpha.-arylacetonitriles (masked acyl anion equivalents) with alkyl dibromides

K Takahashi, M Matsuzaki, K Ogura…

Index: Takahashi, Kazumasa; Matsuzaki, Masahiro; Ogura, Katsuyuki; Iida, Hirotada Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1909 - 1912

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Citation Number: 15

Abstract

Anions derived from a-amino-a-arylacetonitriles are related as masked acyl anion equivalents. The utility of their anions in the formation of carbon-carbon bonds has been reported.'The utilization of such masked acyl anions is, however, not universal. The choice of substituents a to the nitrile group appears to be critical. We report here a new synthetic method for symmetrical diketones by reaction of the masked acyl anions formed from a-(di ...

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