Tritylamino Aromatic Heterocycles and Related Carbinols as Blockers of Ca 2+??Activated Potassium Ion Channels Underlying Neuronal Hyperpolarization

…, Z Miscony, M Javadzadeh??Tabatabaie…

Index: Zunszain, Patricia A.; Shah, Mala M.; Miscony, Zena; Javadzadeh-Tabatabaie, Mazyar; Haylett, Dennis G.; Ganellin, C. Robin Archiv der Pharmazie, 2002 , vol. 335, # 4 p. 159 - 166

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Citation Number: 10

Abstract

Abstract A series of novel aromatic tritylamino heterocycles has been synthesized and the compounds have been tested in comparison with clotrimazole for their ability to inhibit the slow afterhyperpolarization current (sI AHP) in cultured rat hippocampal pyramidal neurones. Some analogues of the clotrimazole metabolite, 2-chlorophenyl-diphenyl methanol, having different chlorination substitution in the triphenyl group have also been ...