Journal of Cardiovascular Pharmacology 1992-01-01

Antiatherosclerotic actions of isradipine.

H Sinzinger, P Fitscha

Index: J. Cardiovasc. Pharmacol. 19 Suppl 3 , S29-31, (1992)

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Abstract

Isradipine, a calcium antagonist of the dihydropyridine type, shows antiatherosclerotic actions that interfere with all three main mechanisms of atherosclerosis. These actions are mediated by the release of prostaglandin I2 and endothelium-derived relaxing factor, and the subsequent elevation of intracellular adenosine-3',5'-cyclic phosphate and 3',5'-guanosine monophosphate, respectively. These mechanisms have been proven in vitro and in animal models. Preliminary data in humans suggest that these mechanisms have clinical relevance in the long-term treatment of patients as well.