Journal of Medicinal Chemistry 1980-12-01

Antihypertensive (2-aminoethyl)thiourea derivatives. 1.

J W Tilley, P Levitan, R W Kierstead, M Cohen

Index: J. Med. Chem. 23(12) , 1387-92, (1980)

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Abstract

Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas. From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog. In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.