Expert Opinion on Drug Metabolism and Toxicology 2008-07-01

New emerging applications of molgramostim in acute myeloid leukaemia.

Xavier Thomas

Index: Expert Opin. Drug Metab. Toxicol. 4(6) , 795-806, (2008)

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Abstract

Human granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates the proliferation and differentiation of hematopoietic progenitor cells in the myeloid lineage, and plays a key role in host defence and the inflammatory process. The main schedules adopted for clinical applications of GM-CSF in acute myeloid leukaemia (AML) were post-chemotherapy, in order to shorten the duration of neutropenia, and as a mobilising agent to induce release of progenitor cells from bone marrow into circulation.