Bioorganic & Medicinal Chemistry Letters 2012-09-01

DBD dyes as fluorescent probes for sensing lipophilic environments.

Robert Wawrzinek, Pablo Wessig, Kristian Möllnitz, Jörg Nikolaus, Roland Schwarzer, Peter Müller, Andreas Herrmann

Index: Bioorg. Med. Chem. Lett. 22(17) , 5367-71, (2012)

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Abstract

Small fluorescent organic molecules based on [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) could be used as probes for lipophillic microenvironments in aqueous solutions by indicating the critical micelles concentration of detergents and staining cell organelles. Their fluorescence lifetime decreases drastically by the amount of water in their direct environment. Therefore they are potential probes for fluorescence lifetime imaging microscopy (FLIM).Copyright © 2012 Elsevier Ltd. All rights reserved.