e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
2-[(Arylmethyl) amino]-2-methyl-1, 3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding
The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA bin-in a series of carbocyclic 2-[(arylmethyl) amino]-2-methyl-l, 3-propan@ ols (AMAPs) were examined. In general, the interaction of AMAPs with DNA increases as the intercalating ring system grows in area, with three distinct binding levels evident. Isomers from a specific ring system appear to bind DNA similarly. DNA binding is not the sole ...
