Journal of Biomedical Materials Research, Part A 2009-09-01

Ethyl-cyanoacrylate is acutely nontoxic and provides sufficient bond strength for anastomosis of peripheral nerves.

Todd Rickett, Jianming Li, Meenal Patel, Wenjing Sun, Gary Leung, Riyi Shi

Index: J. Biomed. Mater. Res. A 90(3) , 750-4, (2009)

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Abstract

Anastomosis is a common technique for the union of severed nerve trunks. This is commonly performed with sutures, a process that can be both time consuming and injurious to tissue. One promising alternative to suturing is the use of adhesives to join the severed segments. Cyanoacrylate-based glues have been used clinically as a surgical adhesive for soft tissues. However, the acute effects of these glues on nerve electrophysiology and the tensile strength of the rejoined tissues have not been evaluated. Using a guinea pig model, we analyzed the mechanical properties of transected sciatic nerves repaired with epineural application of ethyl-cyanoacrylate and the short term consequences of cyanoacrylate application on impulse conduction. Results showed that nerves coapted with ethyl-cyanoacrylate were capable of bearing in vivo forces. Additionally, no acute effects on conduction were observed in uninjured sciatic nerves exposed to ethyl-cyanoacrylate. In conjunction with long term in vivo reports from literature, the current results support the use of cyanoacrylates in nerve repair.