Hygiene and Sanitation 1991-02-01

[Experimental substantiation of MPEL of 3-phenoxybenzyl chloride in water reservoirs].

B M Shtabskiĭ, V I Fedorenko, I I Siarchinskiĭ, M S Avgustinovich, O A Khoma, V M Tomkiv

Index: Gig. Sanit. (2) , 16-9, (1991)

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Abstract

On the basis of experimental studies it was established, that the threshold concentration of 3-phenoxybenzyl chloride (PBC) according to the influence on organoleptic water properties (odour) is 0.03 mg/l, on the sanitary regimen of water reservoirs (BOD inhibition)--0.3 mg/l. The chemical produces low toxicity when administered parenterally, it is highly toxic when administered subcutaneously; cumulation degree is medium. PBC produces a weak allergic effect, an expressed embryotoxic effect; mutagenic activity was not detected. The maximal no-effect dose according to the embryotoxic effect is 0.12 mg/kg (2.4 mg/l), the calculated maximal no-effect concentration is 0.11-0.34 mg/l when administered subcutaneously. The recommended MAC is 0.03 mg/l according to the organoleptic index of harmfulness (odour) with a note 'dangerous when administered through skin' (the third class of danger).