Several substituted aryl and 6-alkylamino analogues of the anticonvulsant purine 9-(2- fluorobenzyl)-6-(methyl-amino)-gH-purine (1) were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Derivatives with a second fluoro substituent in the 5-or 6-position of the aryl moiety were very active with ip ED,% that ranged from 2 to 4 mg/kg. Congeners in which the purine 6- ...
![9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine,hydrochloride Structure](https://image.chemsrc.com/caspic/455/101190-60-7.png)