Bioorganic & Medicinal Chemistry Letters 2004-02-23

Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.

Elizabeth Joshi, Mahendra D Chordia, Timothy L Macdonald, Joel Linden, Ray Olsson

Index: Bioorg. Med. Chem. Lett. 14(4) , 929-33, (2004)

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Abstract

Solutions of 2-amino-3-aroyl-4,5-dialkylthiophenes in DMSO (dimethyl sulfoxide) undergo regioselective oxidation of benzylic carbon under mild conditions. We describe three examples and propose a mechanism for oxidation.