Pharmazie 1990-09-01

Spectrophotometric determination of dapsone by using 9-chloroacridine as a chromogenic reagent.

I Shoukrallah, A Sakla, R Wintersteiger

Index: Pharmazie 45(9) , 675-7, (1990)

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Abstract

A spectrophotometric method for the quantitative determination of dapsone (1) has been developed through a condensation reaction of 9-chloroacridine as a chromogen and the amino groups of 1. The reaction variables were investigated and optimized. The resultant colored products is stable and was synthesized. The application of the present method to the determination of 1 in commercial tablets gave satisfactory results and was compared with the official methods. The proposed method ist simple, sensitive, reproducible and accurate.