Sulfonyl Fluoride??Based Prosthetic Compounds as Potential 18F Labelling Agents

…, S Ait??Mohand, P Schaffer, B Guérin…

Index: Inkster, James A. H.; Liu, Kate; Ait-Mohand, Samia; Schaffer, Paul; Guerin, Brigitte; Ruth, Thomas J.; Storr, Tim Chemistry - A European Journal, 2012 , vol. 18, # 35 p. 11079 - 11087

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Citation Number: 18

Abstract

Abstract Nucleophilic incorporation of [18 F] F− under aqueous conditions holds several advantages in radiopharmaceutical development, especially with the advent of complex biological pharmacophores. Sulfonyl fluorides can be prepared in water at room temperature, yet they have not been assayed as a potential means to 18 F-labelled biomarkers for PET chemistry. We developed a general route to prepare bifunctional 4- ...