Clinical and experimental obstetrics & gynecology 2012-01-01

Holoprosencephaly in clomiphene-induced pregnancy: a possible association? A case report and literature review.

G Eleftheriou, R Butera, L Manzo

Index: Clin. Exp. Obstet. Gynecol. 39(4) , 535-6, (2012)

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Abstract

Clomiphene is widely used for inducing ovulation. Evidence for congenital abnormalities, in particular central nervous system defects (CNS-D) and in babies born from clomiphene-induced pregnancies is conflicting. The authors report a case of holoprosencephalia (HPE) in a fetus delivered from a mother receiving clomiphene.