N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in …

…, EJ Cram, LN Yudina, MN Preobrazhenskaya…

Index: Jump, Sarah M.; Kung, Jenny; Staub, Richard; Kinseth, Matthew A.; Cram, Erin J.; Yudina, Larisa N.; Preobrazhenskaya, Maria N.; Bjeldanes, Leonard F.; Firestone, Gary L. Biochemical Pharmacology, 2008 , vol. 75, # 3 p. 713 - 724

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Citation Number: 26

Abstract

Indole-3-carbinol (I3C), a naturally occurring component of Brassica vegetables, such as cabbage, broccoli, and Brussels sprouts, induces a G1 cell cycle arrest of human breast cancer cells. Structure–activity relationships of I3C that mediate this anti-proliferative response were investigated using synthetic and natural I3C derivatives that contain substitutions at the indole nitrogen. Nitrogen substitutions included N-alkoxy substituents ...