Bioconjugate Chemistry 1992-01-01

Studies of the influence of different cross-linking reagents on the immune response against a B-epitope.

A Delmas, A Brack, Y Trudelle

Index: Bioconjug. Chem. 3(1) , 80-4, (1992)

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Abstract

We have previously shown that the carrier polytuftsin obtained by polycondensation of tuftsin, a naturally occurring macrophage activator, increases significantly the antibody response against a linked B-epitope. In the present work, we have studied the influence of different cross-linking reagents on the quality of the conjugation and on the immune response, at both B-cell and T-cell levels. We observed that the cross-linking method used for coupling the B-epitope to the carrier influences the immune response. A hypothesis is put forward to explain the differences observed.