Aqueous-phase, palladium-catalyzed cross-coupling of aryl bromides under mild conditions, using water-soluble, sterically demanding alkylphosphines

…, LR Moore, KH Shaughnessy

Index: DeVasher, Rebecca B.; Moore, Lucas R.; Shaughnessy, Kevin H. Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 7919 - 7927

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Citation Number: 235

Abstract

Sterically demanding, water-soluble alkylphosphines have been used in combination with various palladium salts in Suzuki, Sonogashira, and Heck couplings of aryl bromides under mild conditions in aqueous solvents. The tert-butyl-substituted ligands 2-(di-tert- butylphosphino) ethyltrimethylammonium chloride (t-Bu-Amphos) and 4-(di-tert- butylphosphino)-N, N-dimethylpiperidinium chloride (t-Bu-Pip-phos) in combination with ...