Synthesis and immunocorrector activity of aromatic sulfonic acid azolides

…, AV Dragunova, LV Limareva, OP Danil'chenko

Index: Purygin; Dragunova; Limareva; Danil'chenko Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 5 p. 247 - 248

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Citation Number: 5

Abstract

Previously we have established that some imidazole and benzimidazole derivatives exhibit cytotoxic and mutagenic action with respect to Drosophila melanogaster larvae [1 ]. Therefore, it was of interest to study the immunocorrector ac- tivity of azolides with respect to the human blood cells. For this purpose, we have synthesized aromatic sulfoacid azolides (Ia, Ib) using the following reaction scheme: ... (Me3Si)2NH 4-RC6H4SO2CI HctH ~ HetSiMe 3 9 R - - ~ /~----SOi--- ...