Journal of Pharmaceutical Sciences 1987-07-01

Thermochemical investigations of associated solutions: 4. Calculation of carbazole-dibutyl ether association constants from measured solubility in binary solvent mixtures.

J W McCargar, W E Acree

Index: J. Pharm. Sci. 76(7) , 572-4, (1987)

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Abstract

Experimental solubilities are reported for anthracene and carbazole in binary dibutyl ether plus n-hexadecane and dibutyl ether plus squalane solvent mixtures at 25 degrees C. Results of these measurements, used in conjunction with the extended nearly ideal binary solvent (NIBS) model, enabled calculation of the carbazole-dibutyl ether association constant. The numerical value obtained was independent of the hydrocarbon cosolvent, and compared favorably with previously reported values based on carbazole solubilities in solvent mixtures containing much smaller alkane cosolvents.