Tetrahedron letters

Reduction of imines via titanium-catalyzed hydromagnesation

SR Amin, WE Crowe

Index: Amin, Sk. Rasidul; Crowe, William E. Tetrahedron Letters, 1997 , vol. 38, # 43 p. 7487 - 7490

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Citation Number: 12

Abstract

We have recently discovered that imines can be reduced to amines via a titanium catalyzed hydromagnesation reaction. These reactions employ n-BuMgCl (1.2 eq) as the stoichiometric reducing agent and Cp2TiCl2 (3–5 mol%) as a catalyst. Reactions are run under nitrogen at ambient temperature and pressure. For most aldimine and cyclic ketimine substrates amine products are obtained in yields ranging from 69–94%. The reaction is ...