Design and synthesis of spirocyclic compounds as HCV replication inhibitors by targeting viral NS4B protein

…, D Garrido, DJ Price, A Maynard, JJ Pouliot…

Index: Tai, Vincent W.-F.; Garrido, Dulce; Price, Daniel J.; Maynard, Andrew; Pouliot, Jeffrey J.; Xiong, Zhiping; Seal, John W.; Creech, Katrina L.; Kryn, Luz H.; Baughman, Todd M.; Peat, Andrew J. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2288 - 2294

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Citation Number: 5

Abstract

Abstract Two novel series of spirocyclic piperidine analogs appended to a pyrazolo [1, 5-a] pyridine core were designed, synthesized and evaluated for their anti-HCV activity. A series of piperidine ketals afforded dispiro 6p which showed excellent in vitro anti-HCV activities (EC 50 of 1.5 nM and 1.2 nM against genotype 1a and 1b replicons, respectively). A series of piperidine oxazolidinones afforded 27c which showed EC 50's of 10.9 nM and 6.1 nM ...