Synthesis and biological evaluation of new 2-(4, 5-dihydro-1 H-imidazol-2-yl)-3, 4-dihydro-2 H-1, 4-benzoxazine derivatives

…, A Arrault, G Guillaumet, E Scalbert…

Index: Navas 3rd., Frank; Bishop, Michael J; Garrison, Deanna T; Hodson, Stephen J; Speake, Jason D; Bigham, Eric C; Drewry, David H; Saussy, David L; Liacos, James H; Irving, Paul E; Gobel, M Jeffrey Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 4 p. 575 - 579

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Citation Number: 81

Abstract

... J. Med ... 28 A third imidazolinic binding site (putative designated I 3 ) in pancreatic β-cells is associated with control of insulin ... a (a) NBS, DMF, 94% yield; (b) HNO 3 /CH 3 COOH/H 2 O, 59% yield; (c) H 2 /Pd/C 10%, methanol, 95% yield; (d) ethyl 2,3-dibromopropanoate, K 2 CO 3 ...