Bioorganic & Medicinal Chemistry Letters 2004-03-08

Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities.

Zhongze Ma, Yoshio Hano, Taro Nomura, Yingjie Chen

Index: Bioorg. Med. Chem. Lett. 14 , 1193-1196, (2004)

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Abstract

Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC(50) 1.8-40.0 microg/mL) and DNA topoisomerase II inhibition at a concentration of 25 microM.