Tetrahedron

Structure–activity relationships of small molecule inhibitors of RAGE-Aβ binding

NT Ross, R Deane, S Perry, BL Miller

Index: Ross, Nathan T.; Deane, Rashid; Perry, Sheldon; Miller, Benjamin L. Tetrahedron, 2013 , vol. 69, # 36 p. 7653 - 7658

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Citation Number: 2

Abstract

Abstract The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-β peptide (Aβ) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure–activity relationships for inhibition of RAGE-Aβ binding, derived from the analysis of a library of tertiary amides.