Design and synthesis of novel potent antinociceptive agents: methyl-imidazolyl N-acylhydrazone derivatives

JM Figueiredo, C de A Câmara, EG Amarante…

Index: Figueiredo, Juliana M.; Camara, Celso De A.; Amarante, Emanuel G.; Miranda, Ana Luisa P.; Santos, Fulvia M.; Rodrigues, Carlos R.; Fraga, Carlos Alberto M.; Barreiro, Eliezer J. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 9 p. 2243 - 2248

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Citation Number: 53

Abstract

This paper describes recent results of design, synthesis and pharmacological evaluation of new N-heterocyclic functionalized N-acylhydrazone compounds, belonging to the 2-methyl- imidazolyl-3-acylhydrazone class (4a–e). These compounds were planned by applying the molecular simplification strategy to propose the structural modifications on the previously described functionalized imidazo [1, 2-a] pyridine 3-acylhydrazone series (2), which ...