Tetrahedron letters

New route to 2-substituted indoles by pyrolysis of N-acylacetylphenylhydroxylamines

K Hirao, K Mohri, O Yonemitsu, M Tabata, J Sohma

Index: Hirao; Mohri; Yonemitsu; Tabata; Sohma Tetrahedron Letters, 1992 , vol. 33, # 11 p. 1459 - 1462

Full Text: HTML

Citation Number: 7

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Convenient and regiospecific synthesis of 2-substituted indol (3) by thermolysis of N-acylacetylphenylhydroxylamine (1 and its mechanism including the formation of a radical intermediate are reported. ... Azoxybenzene (14) was obtained as a by-product in every run. ... An improvement of the yields of 3 by ...

~45%

~47%

~0%

~0%

~0%

~0%

~0%

~0%

~54%

~0%

~42%

~54%

High-affinity inhibitors of dihydrofolate reductase: antimic...

[Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N. Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903]

3-(o-Trifluoroacetamidoaryl)-1-propargylic esters: common in...

[Ambrogio, Ilaria; Cacchi, Sandro; Fabrizi, Giancarlo; Prastaro, Alessandro Tetrahedron, 2009 , vol. 65, # 44 p. 8916 - 8929]

An annulative approach to highly substituted indoles: Unusua...

[Rutherford, Jennifer L.; Rainka, Matthew P.; Buchwald, Stephen L. Journal of the American Chemical Society, 2002 , vol. 124, # 51 p. 15168 - 15169]

An expedient synthesis of substituted indoles

[Smith, Amos B.; Visnick, Melean Tetrahedron Letters, 1985 , vol. 26, # 32 p. 3757 - 3760]