Tetrahedron

Tremorgenic indole alkaloid studies. 6. Preparation of an advanced intermediate for the synthesis of penitrem D. Synthesis of an indole oxocane

AB Smith, JN Haseltine, M Visnick

Index: Smith, III, Amos B.; Visnick, Melean; Haseltine, John N.; Sprengeler, Paul A. Tetrahedron, 1986 , vol. 42, # 11 p. 2957 - 2970

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Citation Number: 32

Abstract

We describe here an efficient synthesis of tricyclic aniline 9, an advanced synthetic intermediate which embodies the BCD rings of the penitrems (A–F), a small family of tremorgenic mycotoxins produced by the ergot fungus Penicillium crustosum. In addition, we