Several novel picolyl alkyl amine derivatives (A− L) were synthesized, and the influence of hydrophobicity and substitution on the inhibition of mushroom tyrosinase toward both monophenolase and diphenolase activities are described. α-, β-, and γ-picolyl amines are neither the substrates nor the inhibitors; however, the inhibition is induced by the incorporation of an alkyl chain. The inhibition was strongly dependent on the substitution ...
