Toxicology in Vitro 2011-12-01

Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons

Shuang Hao, Yong-Ming Bao, Li-Jia An, Wei Cheng, Rong-Guo Zhao, Jing Bi, He-Shuang Wang, Chang-Sen Sun, Ji-Wen Liu, Bo Jiang

Index: Toxicol. In Vitro 25(8) , 1644-53, (2011)

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Abstract

Highlights ► Resibufogenin inhibited both IK and IA in cultured rat hippocampal neurons. ► Cinobufagin inhibited IK without noticeable effect on IA in hippocampal neurons. ► Resibufogenin and Cinobufagin altered some channel kinetics of IK. ► Resibufogenin and Cinobufagin influenced some gating properties of IK.