Tricyclic pharmacophore-based molecules as novel integrin α v β 3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting α v β 3/α IIb β 3 dual …

D Kubota, M Ishikawa, M Yamamoto…

Index: Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2089 - 2108

Full Text: HTML

Citation Number: 25

Abstract

... Bioorganic & Medicinal Chemistry. ... When we started our integrin research program, three major pharmaceutical companies had already reported their original α v β 3 antagonists, including ... Thus, we attempted to enhance the α v β 3 -antagonistic activity by chemical modification. ...