Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

…, C Castaldo, TA Comery, J Dunlop, E Genesio…

Index: Nencini, Arianna; Castaldo, Cristiana; Comery, Thomas A.; Dunlop, John; Genesio, Eva; Ghiron, Chiara; Haydar, Simon; Maccari, Laura; Micco, Iolanda; Turlizzi, Elisa; Zanaletti, Riccardo; Zhang, Jean European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 401 - 418

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Citation Number: 8

Abstract

Abstract α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chemistry program we investigated a novel series of α7 nAChR agonists. Starting from molecular docking studies on two series of molecules recently developed in our laboratories, an alternative scaffold was designed attempting to combine the optimal features of these ...