Sequence specificity of hydrogen-bonded molecular duplexes

H Zeng, H Ickes, RA Flowers…

Index: Zeng, Huaqiang; Miller, Rebecca S.; Flowers II, Robert A.; Gong, Bing Journal of the American Chemical Society, 2000 , vol. 122, # 11 p. 2635 - 2644

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Citation Number: 50

Abstract

Hydrogen-bonded molecular duplexes, 1⊙ 3 and 1⊙ 4, each of which contains a mismatched binding site (acceptor-to-acceptor in 1⊙ 3, and donor-to-donor in 1⊙ 4), were designed and synthesized based on duplex 1⊙ 2. One-and two-dimensional NMR studies demonstrated that, despite their single mismatched binding sites, the backbones of duplexes 1⊙ 3 and 1⊙ 4 still stayed in register through the formation of the remaining five H-bonds. ...