Angewandte Chemie. International edition in English 2009-01-01

Iridium catalysis for C-H bond arylation of heteroarenes with iodoarenes.

Benoît Join, Takuya Yamamoto, Kenichiro Itami

Index: Angew. Chem. Int. Ed. Engl. 48(20) , 3644-7, (2009)

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Abstract

Efficient couplings using equimolar quantities of each coupling partner and multiple C-H bond arylation reactions are achieved with an Ir-based catalytic system for the C-H bond arylation of electron-rich heteroarenes with iodoarenes to construct extended pi-systems. The dramatic ligand effect on reaction efficiency leads to the discovery that Crabtree's catalyst (see scheme) is the optimal catalyst precursor.