Water at elevated temperatures (WET): reactant, catalyst, and solvent in the selective hydrolysis of protecting groups

W Medina-Ramos, MA Mojica, ED Cope, RJ Hart…

Index: Medina-Ramos, Wilmarie; Mojica, Mike A.; Cope, Elizabeth D.; Hart, Ryan J.; Pollet, Pamela; Eckert, Charles A.; Liotta, Charles L. Green Chemistry, 2014 , vol. 16, # 4 p. 2147 - 2155

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Abstract

Water at elevated temperatures (WET) can act simultaneously as reactant, solvent, and catalyst in reaction processes. WET has been successfully employed in the removal of protecting groups alleviating the need for added strong acids/bases, subsequent neutralization and waste salt elimination. The protocols for the water-mediated removal of several common protecting groups such as tert-butyl carbamates (N-Boc) from 125 to 150 ...