e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Fulvestrant: From the laboratory to commercial-scale manufacture

EJ Brazier, PJ Hogan, CW Leung…

Index: Organic Process Research and Development, , vol. 14, # 3 p. 544 - 552

Full Text: HTML

Citation Number: 14

Abstract

... Organic Process Research & Development. ... This procedure prevented formation of the bromo-impurities but led to a slightly elevated level of the Δ6,7-impurity 29. ... Various methods for removal of used copper reagent at the end of the process were investigated. ...

METHANESULFONIC ACID 4,4,5,5,5-PENTAFLUORO-PENTYL ESTER Structure

METHANESULFONIC...

Carbamimidothioic Acid 9-Hydroxynonyl Ester Monobromide Structure

Carbamimidothio...

~%

9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonanol Structure

9-[(4,4,5,5,5-P...

9-bromnonan-1-ol Structure

9-bromnonan-1-ol

~%

9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonanol Structure

9-[(4,4,5,5,5-P...

1,9-Nonanediol Structure

~%

9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonanol Structure

9-[(4,4,5,5,5-P...

4,4,5,5,5-Pentafluoro-1-pentanol Structure

4,4,5,5,5-Penta...

~%

9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonanol Structure

9-[(4,4,5,5,5-P...

9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonanol Structure

9-[(4,4,5,5,5-P...

~%

14-bromo-5-(14-bromo-1,1,1,2,2-pentafluorotetradecan-5-yl)sulfanyl-1,1,1,2,2-pentafluorotetradecane Structure

14-bromo-5-(14-...

METHANESULFONIC ACID 4,4,5,5,5-PENTAFLUORO-PENTYL ESTER Structure

METHANESULFONIC...

~%

14-bromo-5-(14-bromo-1,1,1,2,2-pentafluorotetradecan-5-yl)sulfanyl-1,1,1,2,2-pentafluorotetradecane Structure

14-bromo-5-(14-...

Carbamimidothioic Acid 9-Hydroxynonyl Ester Monobromide Structure

Carbamimidothio...

~%

14-bromo-5-(14-bromo-1,1,1,2,2-pentafluorotetradecan-5-yl)sulfanyl-1,1,1,2,2-pentafluorotetradecane Structure

14-bromo-5-(14-...

9-bromnonan-1-ol Structure

9-bromnonan-1-ol

~%

14-bromo-5-(14-bromo-1,1,1,2,2-pentafluorotetradecan-5-yl)sulfanyl-1,1,1,2,2-pentafluorotetradecane Structure

14-bromo-5-(14-...

1,9-Nonanediol Structure

~%

14-bromo-5-(14-bromo-1,1,1,2,2-pentafluorotetradecan-5-yl)sulfanyl-1,1,1,2,2-pentafluorotetradecane Structure

14-bromo-5-(14-...

4,4,5,5,5-Pentafluoro-1-pentanol Structure

4,4,5,5,5-Penta...

~%

14-bromo-5-(14-bromo-1,1,1,2,2-pentafluorotetradecan-5-yl)sulfanyl-1,1,1,2,2-pentafluorotetradecane Structure

14-bromo-5-(14-...