Rapid Communications in Mass Spectrometry 1994-10-01

Charge-remote fragmentation of peptides derivatized with 4-aminonaphthalenesulphonic acid.

I Lindh, W J Griffiths, T Bergman, J Sjövall

Index: Rapid Commun. Mass Spectrom. 8(10) , 797-803, (1994)

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Abstract

A series of small peptides has been studied by negative-ion fast-atom bombardment mass spectrometry with collision-induced dissociation. It has been found that by derivatizing peptides with 4-aminonaphthalenesulphonic acid in a peptide linkage at the C-terminus, negative-ion formation can be enhanced and fragmentation in collision-induced dissociation reactions controlled. The peptide-naphthalenesulphonates show charge-remote fragmentations and the resultant spectra give sequence information.