Organic Letters 2004-08-19

Polytriazoles as copper(I)-stabilizing ligands in catalysis.

Timothy R Chan, Robert Hilgraf, K Barry Sharpless, Valery V Fokin

Index: Org. Lett. 6 , 2853, (2004)

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Abstract

Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.Copyright 2004 American Chemical Society