Journal of Natural Products 2010-06-25

Compounds from Acorus tatarinowii: determination of absolute configuration by quantum computations and cAMP regulation activity.

Xiao-Gang Tong, Gui-Sheng Wu, Cheng-Gang Huang, Qing Lu, Yue-Hu Wang, Chun-Lin Long, Huai-Rong Luo, Hua-Jie Zhu, Yong-Xian Cheng

Index: J. Nat. Prod. 73 , 1160-3, (2010)

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Abstract

A new cadinane-type sesquiterpenoid, tatarinowin A (1), two phenylpropanoids, tatarinoids A (2) and B (3), and a trinorlignan, tatarinoid C (4), along with 15 known compounds including two pairs of mixtures were isolated from the rhizome of Acorus tatarinowii. The absolute configurations of 1-4 were established by computation of specific rotation values. The isolated compounds were evaluated for their cAMP regulatory activity by the AlphaScreen assay.