Synthetic routes to three novel scaffolds for potential glycosidase inhibitors

M Rommel, A Ernst, U Koert

Index: Rommel, Michael; Ernst, Alexander; Koert, Ulrich European Journal of Organic Chemistry, 2007 , # 26 p. 4408 - 4430

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Citation Number: 13

Abstract

Abstract Efficient syntheses of three novel scaffolds for potential β-glycosidase inhibitors were developed: The first consists of a 2, 7-dioxabicyclo [2.2. 1] heptane derivative, which was prepared by an intramolecular ketalisation. The second scaffold consists of a hydroxylated cyclopentylamine, which could be synthesised stereoselectively from 2- azabicyclo [2.2. 1] hept-5-en-3-one. The third scaffold, a 4, 5-dihydroxynicotinic acid, was ...