Antiallergic properties of certain alkylating organophosphorus compounds

…, LK Nikanorova, NP Grechkin, GS Gubanova

Index: Tomilets, V. A.; Dontsov, V. I.; Nikanorova, L. K.; Grechkin, N. P.; Gubanova, G. S. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 9 p. 638 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 9 p. 34 - 39

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Abstract

Dipropyl Ester of Carbopropoxymethylamidophosphoric Acid (i). Compound (I) is obtained by the reaction of dialkyl phosphites with amino acid esters in the presence of carbon tetrachloride [5]. Triethylamine is used to bind the hydrogen chloride liberated in the reaction. Initially, 50 g of g! ycine propyl ester are added dropwise with stirring and cooling to a solution containing 65.8 g carbon tetrachloride and 70.91 g dipropyl phosphite in ...