Heterocyclic replacement of the central phenyl core of diamine-based histamine H 3 receptor antagonists

…, K Morton, LK Dvorak, C Mazur, R Apodaca…

Index: Swanson, Devin M.; Shah, Chandra R.; Lord, Brian; Morton, Kirsten; Dvorak, Lisa K.; Mazur, Curt; Apodaca, Richard; Xiao, Wei; Boggs, Jamin D.; Feinstein, Mark; Wilson, Sandy J.; Barbier, Ann J.; Bonaventure, Pascal; Lovenberg, Timothy W.; Carruthers, Nicholas I. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4413 - 4425

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Citation Number: 18

Abstract

A series of small molecules consisting of a heterocyclic core flanked by two basic functionalities were synthesized and screened for in vitro affinity at the human histamine H3 receptor (hH3R). Nine of the twenty-eight compounds tested were found to possess a ...