Tetrahedron

The reactions of some halogenated pyridines with methoxide and methanethiolate ions in dimethylformamide

L Testaferri, M Tiecco, M Tingoli, D Bartoli, A Massoli

Index: Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto Tetrahedron, 1985 , vol. 41, # 7 p. 1373 - 1384

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Citation Number: 72

Abstract

The reactions of 2, 6-and 2, 5-dibromopyridines and of 2, 3-and 3, 5-dichloropyridines with sodium isopropanethiolate and methanethiolate afforded the products of mono-or of bis- substitution depending on the experimental conditions. The same pyridines reacted with sodium methoxide to give good yields of the mono-substituted products; bis-substitution occurred easily only in the case of the 2, 6-dibromo-and of the 3, 5-dichloropyridine. The ...

2402-77-9

2,3-Dichloropyridine

~88%

~95%

~90%

~80%

~60%

~6%

~59%

~66%

~74%

~89%

~71%

~90%

~66%

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