Analytical Biochemistry 1984-04-01

The reduction of aliphatic and aromatic N-oxides to the corresponding amines with titanium(III) chloride.

Q F Seaton, C W Lawley, H A Akers

Index: Anal. Biochem. 138(1) , 238-41, (1984)

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Abstract

Amine N-oxides have been observed to be reduced by titanium(III) chloride. To study this reaction, 24 model amine N-oxides were reacted with titanium(III) chloride. The products of these reactions were shown by melting (boiling) points, mixed melting points, derivatives, refractive indices, infrared, and NMR comparisons with authentic compounds to be the corresponding amines. The reductions were found to require 2 moles of titanium(III) per mole of amine N-oxide.