A new general method for the synthesis of medicinally important diversely functionalized imidazoles from N-acylated α-aminonitriles has been developed. N-Acylated α-aminonitriles were reacted with triphenylphosphine and carbon tetrahalide to afford 2, 4-disubstituted 5- halo-1 H-imidazoles in good yield. This new methodology was applied for the synthesis of 2- butyl-4-chloro-5-hydroxymethylimidazole. These halo-imidazoles can be directly ...
