FEBS Letters 1988-08-29

Synthetic magainin analogues with improved antimicrobial activity.

H C Chen, J H Brown, J L Morell, C M Huang

Index: FEBS Lett. 236 , 462, (1988)

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Abstract

Based on modifications to enhance the alpha-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.