Gigiena truda i professional'nye zabolevaniia 1992-01-01

[The toxicokinetics of low-solubility substances (exemplified by 2 boron compounds)].

B A Katsnel'son, L I Konstantinova, L K Konysheva, N N Loboda

Index: Gig. Tr. Prof. Zabol. (5) , 39-42, (1992)

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Abstract

Multichamber toxicokinetic model studies of the resorption, distribution and excretion properties of poorly soluble substances in subchronic action of suspensions administered intragastrically can be the first step in prognosing the toxicokinetic properties of the inhaled aerosols of the substances mostly discharged from the respiratory into the gastrointestinal tract (GIT). The generally accepted quantitative characteristics of the particles' deposition and translocation into GIT can provide a further application of the model for a mathematical description of a prolonged inhalational exposure to some substances. This technique was tested with the boron compounds characterized by low solubility and revealed a good correlation between the prognosed and actual deposits of the substance in the organ and excretions. At the same time, detected were some qualitative and quantitative differences in the boron toxicokinetics influenced by magnesium deboride and hexaborate, which were explained by differences in their solubility.