Organic Letters 2006-03-30

From small building blocks to complex molecular architecture.

Eugene R Zubarev, Jun Xu, Jacob D Gibson, Arshad Sayyad

Index: Org. Lett. 8 , 1367, (2006)

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Abstract

[reaction: see text] We describe a synthesis of a dendrimer-like amphiphile containing a flat rigid core and 12 hydrophobic and hydrophilic arms. We employ a modular approach based on stepwise protection chemistry starting from simple building blocks. The key feature of this approach is the absence of a polymerization step, which makes it applicable for linear monofunctionalized precursors of any kind. This strategy also allows for precise control of the number of arms and ensures their alternating arrangement.