Tetrahedron Letters

Rapid, robust, clean, catalyst-free synthesis of 2-halo-3-carboxyindoles

AR Kunzer, MD Wendt

Index: Kunzer, Aaron R.; Wendt, Michael D. Tetrahedron Letters, 2011 , vol. 52, # 15 p. 1815 - 1818

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Citation Number: 17

Abstract

A novel synthesis of 2-halo-3-carboxyindoles from 2-(2, 2-dihalovinyl) anilines was discovered. Reaction conditions and substrate applicability were studied. Optimally, the reaction takes only minutes when these substrates are heated in DMSO at 120° C in the presence of cesium carbonate. However, the reaction is robust and takes place at a wide range of temperatures, is tolerant of aqueous reaction conditions, and can be performed in ...

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Tyrosine kinase inhibitors. 6. Structure-activity relationsh...

[Showalter, H. D. Hollis; Sercel, Anthony D.; Leja, Boguslawa M.; Wolfangel, Craig D.; Ambroso, Linda A.; Elliott, William L.; Fry, David W.; Kraker, Alan J.; Howard, Curtis T.; Lu, Gina H.; Moore, Charles W.; Nelson, James M.; Roberts, Bill J.; Vincent, Patrick W.; Denny, William A.; Thompson, Andrew M. Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 413 - 426]

Rapid, robust, clean, catalyst-free synthesis of 2-halo-3-ca...

[Tetrahedron Letters, , vol. 52, # 15 p. 1815 - 1818]