Research communications in chemical pathology and pharmacology 1982-07-01

Effects of nitroglycerin and ethylene glycol dinitrate mixture (blasting oil) on rat brain, liver and kidney.

A Zitting, H Savolainen

Index: Res. Commun. Chem. Pathol. Pharmacol. 37(1) , 113-21, (1982)

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Abstract

Rats were injected intraperitoneally (150 mg/kg) with a mixture of nitroglycerin and ethylene glycol dinitrate (1:3). Treatment caused a transient small increase in methemoglobin contents in blood and diminished contents of reduced glutathione in liver and brain. Hepatic cytochrome P-450 concentration and ethoxycoumarin deethylase activity decreased shortly after exposure but later the effect disappeared. Succinate dehydrogenase activity decreased in liver, kidney and brain. In brain, activity of creatine kinase increased significantly and slight increase in hepatic UDPglucuronosyltransferase and epoxide hydrolase activity was observed. Renal ethoxycoumarin activity increased transiently. The results point to interaction of hydrolytically released nitrite with hemoproteins.